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KMID : 0371319960500050659
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Journal of the Korean Surgical Society
1996 Volume.50 No. 5 p.659 ~ p.665
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Significance of Metastasis Regulation Gene Protien(nm23) Expression in Ductal carcinoma in Situ of the Breast
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배정원
이은숙/구범환/황정웅/김인선
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Abstract
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The nm23 gene was originally identified by Steeg et al by screening of cDNA libraries from murine melanoma cell lines of varying metastatic potential. Most ductal carcinoma in situ lesions are at least nonobligate precursors of invasive
carcinoma.
Ductal carcinoma in situ is is a heterogeneous group composed of several distinct subtypes. In order to determine whether nm23 expression serves as a marker of tumor progression and whether hyperproliferative neoplastic cells would correlate with
expression, we analyzed metastasis regulation gene expression by immunohistochemical staining in 5 severe ductal hyperplasias, 12 ductal carcinoma in situ, and 11 ductal carcinoma in situ accompanying invasive components.
Our results showed that nm23 expression increased more in pure ductal carcinoma in situ than in intraductal carcinoma accompanying focal invasive components and can be considered as a biological marker of tumor progression. There was no
expression
of
nm23 gene protein in 2 patients of focal invasive carcinomas accompanying axillary lymphnodes metastases. No correlation was observed between nm23 expression and histologic grades. It may have value for choosing whether or not axillary dissection
in
early breast cancer operation is necessary. The mechanism of nm23 gene expression in advanced cancer and its role in tumor progression and metastatic potential remain to be determined.
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KEYWORD
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